Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …

Multi-omics data analysis is an important aspect of cancer molecular biology studies and
has led to ground-breaking discoveries. Many efforts have been made to develop machine …

Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …

We present a statistical simulator, scDesign3, to generate realistic single-cell and spatial
omics data, including various cell states, experimental designs and feature modalities, by …

Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally
diverse; however, the extent and determinants of neutrophil heterogeneity in humans remain …

Comprehensive molecular analyses of metastatic hepatocellular carcinoma (HCC) are
lacking. Here, we generate multi-omic profiling of 257 primary and 176 metastatic regions …

Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …

Abstract Alveolar epithelial type 1 (AT1) cells are necessary to transfer oxygen and carbon
dioxide between the blood and air. Alveolar epithelial type 2 (AT2) cells serve as a partially …

Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the
discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin …