Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This
may be of particular importance in the context of immune receptors, such as the B cell …

A pool of MHC-I molecules present at the plasma membrane can dissociate from the peptide
and/or the light chain, becoming open MHC-I conformers. Whereas peptide-bound MHC-I …

Major histocompatibility complex class I (MHCI) molecules modulate activity-dependent
refinement and plasticity. We found that MHCI also negatively regulates the density and …

The combination of biology and nanotechnology has led to a new generation of
nanodevices that make it possible to characterize the chemical, mechanical, and other …

Abstract Leukocyte Ig-like receptors (LILRs) are a family of innate immune receptors
predominantly expressed by myeloid cells that can alter the Ag presentation properties of …

Background Single antigen flow beads assays may overestimate sensitization because of
the detection of supposedly irrelevant antibodies recognizing denatured class I human …

Studies carried out during the last few decades have consistently shown that cell surface
MHC class I (MHC-I) molecules are endowed with functions unrelated with antigen …

T cell recognition of peptide-MHC is highly specific and is sensitive to very low levels of
agonist peptide; however, it is unclear how this effect is achieved or regulated. In this study …

Knowledge of the origin and biochemical status of β 2-microglobulin-free or misfolded major
histocompatibility complex (MHC)-I molecules is essential for understanding their pleiotropic …

Anti‐HLA donor‐specific antibodies are deleterious for organ transplant survival. Class I
HLA donor‐specific antibodies are identified by using the Luminex single antigen beads …