Gram-negative bacteremia is a devastating public health threat, with high mortality in
vulnerable populations and significant costs to the global economy. Concerningly, rates of …

Due to the continued emergence of resistance and a lack of new and promising antibiotics,
bacterial infection has become a major public threat. High-throughput screening (HTS) …

Klebsiella pneumoniae are Gram-negative facultative anaerobes that are found within host-
associated commensal microbiomes, but they can also cause a wide range of infections that …

Our knowledge about the fundamental aspects of biofilm biology, including the mechanisms
behind the reduced antimicrobial susceptibility of biofilms, has increased drastically over the …

Revitalizing antibiotic discovery and development through in vitro modelling of in-patient
conditions | Nature Microbiology Skip to main content Thank you for visiting nature.com. You …

The minimal inhibitory concentration (MIC) assay uses agar or broth dilution methods to
measure, under defined test conditions, the lowest effective concentration of an antimicrobial …

Summary β-Lactam antibiotics disrupt the assembly of peptidoglycan (PG) within the
bacterial cell wall by inhibiting the enzymatic activity of penicillin-binding proteins (PBPs). It …

Novel approaches are required to address the looming threat of pan-resistant Gram-
negative pathogens and forestall the rise of untreatable infections. Unconventional targets …

Gram-negative bacteremia is a major cause of global morbidity involving three phases of
pathogenesis: initial site infection, dissemination, and survival in the blood and filtering …

Identification of new antibiotics remains a huge challenge. The last antibiotic of new
chemical class and mechanism was discovered more than 30 years ago. Advances since …