Limited proteolysis is responsible for activating a wide range of proteins from immature
forms and is hence implicated in a number of biologically imporw x tant systems 1–3 …

Proteinases perform many beneficial functions that are essential to life, but they are also
dangerous and must be controlled. Here we focus on one of the control mechanisms: the …

Motivation: Empirical models for the prediction of how changes in sequence alter protein–
protein binding kinetics and thermodynamics can garner insights into many aspects of …

Human defensins form a family of small, cationic, and Cys-rich antimicrobial proteins that
play important roles in innate immunity against invading microbes. They also function as …

LEKTI is a 15-domain serine proteinase inhibitor whose defective expression underlies the
severe autosomal recessive ichthyosiform skin disease, Netherton syndrome. Here, we …

The oomycetes form one of several lineages within the eukaryotes that independently
evolved a parasitic lifestyle and consequently are thought to have developed alternative …

Serine proteases and their natural protein inhibitors are among the most intensively studied
protein complexes. About 20 structurally diverse inhibitor families have been identified …

The synthetic utility of proteases has been recognized long before their chemical nature was
known. In 1783, Spallazani postulated from his experiments that gastric juice bears an …

The serine protease subtilisin is an important industrial enzyme as well as a model for
understanding the enormous rate enhancements affected by enzymes. For these reasons …

The plant apoplast forms a protease-rich environment in which proteases are integral
components of the plant defense response. Plant pathogenic oomycetes, such as the potato …