Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …

Lysosomes are of major importance for the regulation of cellular cholesterol homeostasis.
Food-derived cholesterol and cholesterol esters contained within lipoproteins are delivered …

Cholesteryl ester storage disease (CESD) is caused by deficient lysosomal acid lipase (LAL)
activity, predominantly resulting in cholesteryl ester (CE) accumulation, particularly in the …

Lysosomal acid lipase deficiency is a rare, autosomal recessive condition caused by
mutations in the gene encoding lysosomal acid lipase (LIPA) that result in reduced or absent …

AIM: To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease
(NAFLD) onset, severity, and outcome through systematic literature review. METHODS: The …

Cholesteryl ester storage disease (CESD) and Wolman disease are autosomal recessive
later‐onset and severe infantile disorders, respectively, which result from the deficient …

The interpretation of genomic variants has become one of the paramount challenges in the
post-genome sequencing era. In this review we summarize nearly 20 years of research on …

Background & Aims Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive
condition that may present in a mild form (cholesteryl ester storage disease [CESD]), which …

Targeting autophagy is a promising therapeutic approach in cancer therapy. Here, we
screened 30 traditional herbal medicines to identify novel autophagy regulators and found …

Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of excessive
intrahepatic fat, is a leading metabolic disorder also considered as the hepatic manifestation …