More than one-third of the worldwide population is overweight or obese and therefore at risk
of develo** type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Obesity develops from a prolonged imbalance of energy intake and energy expenditure.
However, the relatively recent discovery that the composition and function of the gut …

Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

Of the many genetic obesity syndromes, none have been as intensively studied as ob/ob
and db/db mice. These two mutant mice were originally identified over 30 years ago (1, 2) …

Introduction thermogenesis. The latter, at least in rodents, involves The ability to assure
continuous availability of energy the function of brown adipose tissue (BAT; Lowell and …

The past few years of research on leptin have provided important information on the link
between metabolism and immune homeostasis. Adipocytes influence not only the endocrine …

The mechanisms involved in body weight regulation in humans include genetic,
physiological, and behavioral factors. Stability of body weight and body composition …

Energy availability influences reproductive fitness. The activity of the reproductive axis is
sensitive to the adequacy of nutrition and the stores of metabolic reserves. The adipocyte …

Leptin, the protein encoded by the obese (ob) gene, is secreted from adipose tissue and is
thought to act in the central nervous system to regulate food intake and body weight,. It has …

Fatty livers of obese fa/fa rats are vulnerable to injury when challenged by insults such as
endotoxin, ischemia‐reperfusion or acute ethanol treatment. The objective of this study was …