Gastrointestinal stromal tumours: origin and molecular oncology
CL Corless, CM Barnett, MC Heinrich - Nature Reviews Cancer, 2011 - nature.com
Gastrointestinal stromal tumours (GISTs) are a paradigm for the development of
personalized treatment for cancer patients. The nearly simultaneous discovery of a …
personalized treatment for cancer patients. The nearly simultaneous discovery of a …
[HTML][HTML] The GIST of advances in treatment of advanced gastrointestinal stromal tumor
Gastrointestinal stromal tumor (GIST) is the most common malignant neoplasm of
mesenchymal origin and a compelling clinical and biologic model for the rational …
mesenchymal origin and a compelling clinical and biologic model for the rational …
miR-34a repression of SIRT1 regulates apoptosis
M Yamakuchi, M Ferlito… - Proceedings of the …, 2008 - National Acad Sciences
MicroRNA 34a (miR-34a) is a tumor suppressor gene, but how it regulates cell proliferation
is not completely understood. We now show that the microRNA miR-34a regulates silent …
is not completely understood. We now show that the microRNA miR-34a regulates silent …
Molecular pathobiology of gastrointestinal stromal sarcomas
CL Corless, MC Heinrich - Annu. Rev. Pathol. Mech. Dis., 2008 - annualreviews.org
Gastrointestinal stromal tumors (GISTs) form an interesting group of sarcomas whose unique
pathobiology provides a model of how molecularly targeted therapeutics can have a major …
pathobiology provides a model of how molecularly targeted therapeutics can have a major …
[HTML][HTML] Gastrointestinal stromal tumors: what do we know now?
CL Corless - Modern Pathology, 2014 - Elsevier
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the GI
tract, arising from the interstitial cells of Cajal, primarily in the stomach and small intestine …
tract, arising from the interstitial cells of Cajal, primarily in the stomach and small intestine …
Update on molecular genetics of gastrointestinal stromal tumors
I Brčić, A Argyropoulos, B Liegl-Atzwanger - Diagnostics, 2021 - mdpi.com
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the
gastrointestinal tract. The majority are sporadic, solitary tumors that harbor mutually …
gastrointestinal tract. The majority are sporadic, solitary tumors that harbor mutually …
Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications
Z Szucs, K Thway, C Fisher, R Bulusu… - Future …, 2017 - Taylor & Francis
Gastrointestinal stromal tumors (GISTs) are composed of various molecular subtypes, with
differing prognostic and predictive relevance. Previously, tumors lacking mutations in the KIT …
differing prognostic and predictive relevance. Previously, tumors lacking mutations in the KIT …
What is new in gastrointestinal stromal tumor?
The classification “gastrointestinal stromal tumor”(GIST) became commonplace in the 1990s
and since that time various advances have characterized the GIST lineage of origin, tyrosine …
and since that time various advances have characterized the GIST lineage of origin, tyrosine …
Targeted cancer therapies in the twenty‐first century: lessons from imatinib
F Stegmeier, M Warmuth, WR Sellers… - Clinical Pharmacology …, 2010 - Wiley Online Library
An increased understanding of the molecular etiology of cancer has enabled the
development of novel therapies that are collectively referred to as molecular targeted …
development of novel therapies that are collectively referred to as molecular targeted …
Gastrointestinal stromal tumors: the GIST of precision medicine
The discovery of activated KIT mutations in gastrointestinal (GI) stromal tumors (GISTs) in
1998 triggered a sea change in our understanding of these tumors and has ushered in a …
1998 triggered a sea change in our understanding of these tumors and has ushered in a …