Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pum** throughout the mammal's lifespan. This process is …

Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed
characterization of the human heart is necessary; however, this has been largely impeded …

The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Background: Pressure overload–induced pathological cardiac hypertrophy is a common
predecessor of heart failure, the latter of which remains a major cardiovascular disease with …

The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how
lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo …

Current therapies for heart failure after myocardial infarction are limited and non-curative.
Although regenerative approaches are receiving significant attention, clinical efforts that …

Aging is associated with a progressive decline in cardiovascular structure and function.
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …

Epigenetics is one of the most rapidly expanding fields in biology. The recent
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …

Abstract The mammalian SWItch/Sucrose Non-Fermentable (SWI/SNF) helicase SMARCA4
is frequently mutated in cancer and inactivation results in a cellular dependence on its …