Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Transglutaminase 2 (TG2 or tissue transglutaminase) is a highly complex multifunctional
protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and …

Hsp70 is a highly conserved and inducible heat shock protein that belongs to the HSP70
family of molecular chaperones and plays a central role in protein homeostasis. The main …

Acute kidney injury (AKI) represents a common complication in critically ill patients that is
associated with increased morbidity and mortality. In a murine AKI model induced by …

Cancer may result from localized failure of instructive cues that normally orchestrate cell
behaviors toward the patterning needs of the organism. Steady-state gradients of …

Heat shock protein 70 (Hsp70) is frequently overexpressed in tumor cells. An unusual cell
surface localization could be demonstrated on a large variety of solid tumors including lung …

The high frequency of breast cancer worldwide and the high mortality among women with
this malignancy are a serious challenge for modern medicine. A deeper understanding of …

The discovery that cancer cells generate large membrane-enclosed packets of epigenetic
information, known as microvesicles (MVs), that can be transferred to other cells and …

The significant influence of tumor microenvironment on malignant cells has been
investigated with enthusiasm in this era of targeted therapy. Transglutaminase 2 (TG2, EC …

Elevated expression of the inducible heat shock protein 70 (Hsp70) is known to correlate
with poor prognosis in many cancers. Hsp70 confers survival advantage as well as …