Cardiac glycosides, derived from plants and animals, have been recognized since ancient
times. These substances hinder the function of the sodium–potassium pump within …

Studies have found that RNA-binding proteins (RBPs) are dysfunctional and play a
significant regulatory role in the development of glioma. Based on The Cancer Genome …

In women, breast cancer (BC) accounts for 7%–10% of all cancer cases and is one of the
most common cancers. To identify a new method for treating BC, the role of CD93 and its …

The outbreak of the SARS-CoV-2 virus in December 2019 has caused the deaths of several
hundred thousand people worldwide. Currently, the pathogenesis of COVID-19 is poorly …

Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the
differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively …

The role of epigenetic mechanisms in the regulation of the human RORγT gene, which
encodes a Th17 lymphocyte signature transcription factor, remains largely unknown. We …

Two isoforms of a ligand-activated nuclear receptor, RORγ and RORγT, have been
implicated in various physiological functions, including energy metabolism, circadian rhythm …

RORγT is a protein product of the RORC gene belonging to the nuclear receptor subfamily
of retinoic-acid-receptor-related orphan receptors (RORs). RORγT is preferentially …

Human T-cell leukemia virus type 1 (HTLV-1), a retrovirus, is the causative agent for adult T
cell leukemia/lymphoma and many other human diseases. Accurate and high throughput …

The universal nine-amino-acid transactivation domains (9aaTADs) have been identified in
numerous transcription activators. Here, we identified the conserved 9aaTAD motif in all …