Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Plant-associated endophytes define an important symbiotic association in nature and are
established bio-reservoirs of plant-derived natural products. Endophytes colonize the …

Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …

Covering: 1877 to 2020 A key challenge in natural products research is the selection of
biodiversity to yield novel chemistry. Recently, marine microorganisms have become a …

Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …

Sea sponges are the largest marine source of small-molecule natural products described to
date. Sponge-derived molecules, such as the chemotherapeutic eribulin, the calcium …

Cyclic peptide natural products represent an important class of bioactive compounds and
clinical drugs. Enzymatic side-chain macrocyclization of ribosomal peptides is a major …

Bacterial natural products display astounding structural diversity, which, in turn, endows
them with a remarkable range of biological activities that are of significant value to modern …

Bacterial specialized metabolites are increasingly recognized as important factors in animal–
microbiome interactions: for example, by providing the host with chemical defenses. Even in …