Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Obesity, a growing health problem worldwide, has been associated with the metabolic
syndrome, diabetes, cardiovascular disease, hypertension, and other chronic diseases …

Calorie restriction or changes in dietary composition can enhance healthy aging, but the
inability of most subjects to adhere to chronic and extreme diets, as well as potentially …

Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Background Body-mass index (the weight in kilograms divided by the square of the height in
meters) is known to be associated with overall mortality. We investigated the effects of age …

The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell
proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF …

The ageing of populations worldwide is leading to an unprecedented increase in cancer
cases and fatalities. Understanding the links between cancer and ageing is therefore more …

The insulin-like growth factor 1 (IGF1) signalling pathway has important roles in regulating
cellular proliferation and apoptosis. Converging results from epidemiological research and …

Dietary restriction has been shown to have several health benefits including increased
insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The …

IGF-I receptor (IGF-IR) signaling and functions are mediated through the activities of a
complex molecular network of positive (eg., type I IGF) and negative (eg., the type II IGF …