Chimeric antigen receptor T cell and chimeric antigen receptor NK cell therapy in pediatric and adult high-grade glioma—Recent advances

A Kowalczyk, J Zarychta, A Marszołek, J Zawitkowska… - Cancers, 2024 - mdpi.com
Simple Summary High-grade gliomas (HGG), both in children and adults, are rare tumors.
However, due to the dismal prognosis, they constitute a significant clinical problem …

Therapeutically targeting the unique disease landscape of pediatric high-grade gliomas

D Fernando, AU Ahmed, BRG Williams - Frontiers in Oncology, 2024 - frontiersin.org
Pediatric high-grade gliomas (pHGG) are a rare yet devastating malignancy of the central
nervous system's glial support cells, affecting children, adolescents, and young adults …

Pediatric central nervous system cancers, version 2.2023, NCCN clinical practice guidelines in oncology

A Gajjar, A Mahajan, M Abdelbaki, C Anderson… - Journal of the National …, 2022 - jnccn.org
Central nervous system (CNS) cancers account for approximately one quarter of all pediatric
tumors and are the leading cause of cancer-related death in children. More than 4,000 brain …

Clinical features and outcomes of pediatric intracranial gliomas: results from single center's 226 cases and corroborated with SEER database

Z Chen, Z Guo, J Wang, D Cao, Y Xu, F Dong… - Child's Nervous …, 2023 - Springer
Background Pediatric gliomas are the most common central nervous system (CNS) tumors
in children and adolescents and show different clinical and histopathological characteristics …

Resistance mechanisms in BRAFV600E paediatric high-grade glioma and current therapeutic approaches

R Lehmann, BS Rayner, DS Ziegler - Frontiers in oncology, 2022 - frontiersin.org
Paediatric high-grade gliomas (pHGG) are aggressive central nervous system tumours with
a poor prognosis. BRAFV600E mutant pHGGs can be treated with targeted BRAF inhibitors …

Brazilian pediatric patients with gliomas: treatment characteristics and survival outcomes

MTM Starling, AAL Pereira, G Viani… - Reports of Practical …, 2024 - journals.viamedica.pl
Background: The current study aimed to determine the overall survival (OS) rates of patients
diagnosed with pediatric gliomas in Brazil, accounting for the influence of age, treatmen tm …