The attachment of cells to the extracellular matrix (ECM) is the hallmark of structure–function
stability and well-being. ECM detachment in localized tumors precedes abnormal …

During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …

Breast cancer has become a serious threat to women's health. Cancer progression is mainly
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …

One of the classic hallmarks of cancer is the imbalance between elevated cell proliferation
and reduced cell death. Ceramide, a bioactive sphingolipid that can regulate this balance …

Breast cancer (BC) remains the most common cancer, as well as the leading cause of
cancer mortality in women worldwide. Approximately 30% of patients with early-stage BC …

The only enzyme in the glycosphingolipid (GSL) metabolic pathway, which produces
glucosylceramide (GlcCer) de novo is UDP-glucose ceramide glucosyltransferase (UGCG) …

Background Metabolic stress resulting from nutrient deficiency is one of the hallmarks of a
growing tumour. Here, we tested the hypothesis that metabolic stress induces breast cancer …

UDP-glucose ceramide glucosyltransferase (UGCG) is the first key enzyme in
glycosphingolipid (GSL) metabolism that produces glucosylceramide (GlcCer). Increased …

Ceramides, the core of the sphingolipid metabolism, draw wide attention as tumor
suppressor, and act directly on mitochondria to trigger apoptotic cell death. Ceramide-based …

A growing number of studies describe a connection between glycosphingolipids (GSLs) and
glutamine metabolism, glucose metabolism and mitochondrial dysfunction in cancer cells …