Historically, the human brain has been conceptually segregated from the periphery and
further dichotomized into gray matter (GM) and white matter (WM) based on the whitish …

Current psychiatric diagnostic schema segregate symptom clusters into discrete entities,
however, large proportions of patients suffer from comorbid conditions that fit neither …

Aging is associated with appearance of white matter hyperintensities (WMH) on MRI scans.
Vascular risk and inflammation, which increase with age, may contribute to white matter …

Schizophrenia is believed to result from altered neuronal connectivity and impaired
myelination. However, there are few direct evidence for myelin abnormalities in …

The integrity of brain white matter connections is central to a patient's ability to respond to
pharmacological interventions. This study tested this hypothesis using a specific measure of …

Second-generation antipsychotics are utilized extensively in the treatment of psychotic
disorders and other psychiatric conditions, but the effects of these medications on human …

Schizophrenia is one of the most severe psychiatric diseases noted for its chronic and often
debilitating processes; affecting approximately 1% of the world's population, while its …

Lithium is the mainstay for the treatment of bipolar disorder (BD) and inhibits glycogen
synthase kinase 3-β (GSK3-β). The less active GSK3-β promoter gene variants have been …

Myelin and oligodendrocyte dysfunctions have been consistently found in patients with
schizophrenia. The effect of antipsychotics on myelin disturbances is unknown. The present …

Cognitive impairment is a core feature of schizophrenia. However, the longitudinal course
and pattern of this impairment, and its relationship to functional outcome, are not fully …