The mating pheromone a-factor secreted by Saccharomyces cerevisiae is a farnesylated
and carboxylmethylated peptide and is unusually hydrophobic compared to other …

We have extended the technique of PCR-directed recombination in Saccharomyces
cerevisiae to develop a simple method for plasmid or gene construction in the absence of …

The Saccharomyces cerevisiae mating pheromone a-factor is a prenylated and carboxyl
methylated extracellular peptide signaling molecule. Biogenesis of the a-factor precursor …

We are studying the intracellular trafficking of the multispanning membrane protein Ste6p,
the a-factor transporter in Saccharomyces cerevisiae and a member of the ATP-binding …

Of the 125 plasma membrane transporters thus far identified in the yeast S. cerevisiae, a
growing number is reported to be subject to tight control at membrane trafficking level, in …

The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508
(ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane …

The gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), an
ATP binding cassette (ABC) transporter that functions as a phosphorylation-and nucleotide …

Eukaryotic proteins containing a C-terminal CAAX motif undergo a series of posttranslational
CAAX-processing events that include isoprenylation, C-terminal proteolytic cleavage, and …

The ATP binding cassette (ABC) transporter protein Yor1p was identified on the basis of its
ability to elevate oligomycin resistance when it was overproduced from a high-copy-number …

The folding of nascent secretory and membrane proteins is monitored by the endoplasmic
reticulum (ER) quality control system. Misfolded proteins are retained in the ER and can be …