Glutaminases regulate glutathione and oxidative stress in cancer
JM Matés, JA Campos-Sandoval… - Archives of …, 2020 - Springer
Targeted therapies against cancer have improved both survival and quality of life of patients.
However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic …
However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic …
Targeting Wnt signaling in endometrial cancer
Simple Summary Wnt has diverse regulatory roles at multiple cellular levels and numerous
targeting points, and aberrant Wnt signaling has crucial roles in carcinogenesis, metastasis …
targeting points, and aberrant Wnt signaling has crucial roles in carcinogenesis, metastasis …
[HTML][HTML] Patient-derived xenografts (PDXs) as model systems for human cancer
F Invrea, R Rovito, E Torchiaro, C Petti, C Isella… - Current opinion in …, 2020 - Elsevier
Highlights•PDXs are obtained by growing human tumours into immunocompromised
mice.•Expansion of tumours as PDXs provides unlimited material for molecular …
mice.•Expansion of tumours as PDXs provides unlimited material for molecular …
The role of WNT10B in physiology and disease: a 10-year update
WNT10B, a member of the WNT family of secreted glycoproteins, activates the WNT/β-
catenin signaling cascade to control proliferation, stemness, pluripotency, and cell fate …
catenin signaling cascade to control proliferation, stemness, pluripotency, and cell fate …
Chemo–immunotherapy for chemo-resistance and metastasis of triple-negative breast cancer by combination of iron-oxide nanoparticles and dual-targeting …
H Hu, L Yu, Z Ding, J Ding, Y Hu, Z Yin - Chinese Chemical Letters, 2023 - Elsevier
Triple-negative breast cancer (TNBC) lacks specific regimens for targeted therapy. Repeat
chemotherapy promotes the evolution of TNBC into highly chemo-resistant tumors that …
chemotherapy promotes the evolution of TNBC into highly chemo-resistant tumors that …
[HTML][HTML] Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis
Colorectal cancer (CRC) is a leading cause of the cancer-related deaths worldwide. Thus,
develo** novel and targeted therapies for inhibiting CRC progression and metastasis is …
develo** novel and targeted therapies for inhibiting CRC progression and metastasis is …
Targeting histone modifications in breast cancer: a precise weapon on the way
W Li, H Wu, S Sui, Q Wang, S Xu… - Frontiers in cell and …, 2021 - frontiersin.org
Histone modifications (HMs) contribute to maintaining genomic stability, transcription, DNA
repair, and modulating chromatin in cancer cells. Furthermore, HMs are dynamic and …
repair, and modulating chromatin in cancer cells. Furthermore, HMs are dynamic and …
Recent progress in small molecule agents for the targeted therapy of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive type of cancer, with a high risk
of death on recurrence. To date, there is a lack of approved targeted agents for the treatment …
of death on recurrence. To date, there is a lack of approved targeted agents for the treatment …
Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming
T Lopatina, C Grange, C Cavallari, V Navarro-Tableros… - Oncogenesis, 2020 - nature.com
The lack of approved targeted therapies highlights the need for new treatments for triple-
negative breast cancer (TNBC) patients. Interleukin-3 (IL-3) acts as an autocrine factor for …
negative breast cancer (TNBC) patients. Interleukin-3 (IL-3) acts as an autocrine factor for …
MASTL regulates EGFR signaling to impact pancreatic cancer progression
Pancreatic cancer (PC) remains a major cause of cancer-related deaths primarily due to its
inherent potential of therapy resistance. Checkpoint inhibitors have emerged as promising …
inherent potential of therapy resistance. Checkpoint inhibitors have emerged as promising …