Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …
[HTML][HTML] In vitro techniques and measurements of phage characteristics that are important for phage therapy success
Validated methods for phage selection, host range expansion, and lytic activity
determination are indispensable for maximizing phage therapy outcomes. In this review, we …
determination are indispensable for maximizing phage therapy outcomes. In this review, we …
Bacteriophage adsorption: Likelihood of virion encounter with bacteria and other factors affecting rates
For ideal gasses, the likelihood of collision of two molecules is a function of concentrations
as well as environmental factors such as temperature. This too is the case for particles …
as well as environmental factors such as temperature. This too is the case for particles …
Antibiotics that affect translation can antagonize phage infectivity by interfering with the deployment of counter-defenses
It is becoming increasingly clear that antibiotics can both positively and negatively impact
the infectivity of bacteriophages (phage), but the underlying mechanisms often remain …
the infectivity of bacteriophages (phage), but the underlying mechanisms often remain …
New antimicrobial strategies to treat multi-drug resistant infections caused by gram-negatives in cystic fibrosis
People with cystic fibrosis (CF) suffer from recurrent bacterial infections which induce
inflammation, lung tissue damage and failure of the respiratory system. Prolonged exposure …
inflammation, lung tissue damage and failure of the respiratory system. Prolonged exposure …
Bacteriophages: The promising therapeutic approach for enhancing ciprofloxacin efficacy against bacterial infection
Background The emergence of ciprofloxacin‐resistant bacteria is a serious challenge
worldwide, bringing the need to find new approaches to manage this bacterium …
worldwide, bringing the need to find new approaches to manage this bacterium …
Bacteriophage–Antibiotic Combination Therapy against Pseudomonas aeruginosa
G Santamaría-Corral, A Senhaji-Kacha… - Antibiotics, 2023 - mdpi.com
Phage therapy is an alternative therapy that is being used as the last resource against
infections caused by multidrug-resistant bacteria after the failure of standard treatments …
infections caused by multidrug-resistant bacteria after the failure of standard treatments …
[HTML][HTML] The Potential of Phage Treatment to Inactivate Planktonic and Biofilm-Forming Pseudomonas aeruginosa
I Martinho, M Braz, J Duarte, A Brás, V Oliveira… - Microorganisms, 2024 - mdpi.com
Pseudomonas aeruginosa is a common cause of hospital-acquired infections and exhibits a
strong resistance to antibiotics. An alternative treatment option for bacterial infections is the …
strong resistance to antibiotics. An alternative treatment option for bacterial infections is the …
Warming alters life-history traits and competition in a phage community
Host-parasite interactions are highly susceptible to changes in temperature due to
mismatches in species thermal responses. In nature, parasites often exist in communities …
mismatches in species thermal responses. In nature, parasites often exist in communities …
[HTML][HTML] Automating predictive phage therapy pharmacology
Viruses that infect as well as often kill bacteria are called bacteriophages, or phages.
Because of their ability to act bactericidally, phages increasingly are being employed …
Because of their ability to act bactericidally, phages increasingly are being employed …