Because of the compartmentalization of disciplines that shaped the academic landscape of
biology and biomedical sciences in the past, physiological systems have long been studied …

Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …

Major depression is characterized by diverse debilitating symptoms that include
hopelessness and anhedonia. Dopamine neurons involved in reward and motivation …

Data from clinical and preclinical studies indicate that immune dysregulation, specifically of
inflammatory processes, is associated with symptoms of major depressive disorder (MDD) …

Social stress is associated with altered immunity and higher incidence of anxiety-related
disorders. Repeated social defeat (RSD) is a murine stressor that primes peripheral myeloid …

Repeated environmental stress has been proposed to induce neural inflammation together
with depression and anxiety. Innate immune receptors, such as Toll-like receptors (TLRs) …

The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …

The evolution of mass spectrometry (MS) and analytical techniques has led to the demand
for proteome analysis with high proteome coverage in single-shot measurements. Focus has …

Microglia are activated in many neurological diseases and have been suggested to play an
important role in the development of affective disorders including major depression. To …

Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …