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Insights into the medicinal chemistry of heterocycles integrated with a pyrazolo [1, 5-a] pyrimidine scaffold
Pyrazolo [1, 5-a] pyrimidines are the dominant motif of many drugs; for instance, zaleplon
and indiplon are sedative agents and ocinaplon was identified as an anxiolytic agent. The …
and indiplon are sedative agents and ocinaplon was identified as an anxiolytic agent. The …
Aminoazole-based diversity-oriented synthesis of heterocycles
The comprehensive review contains the analysis of literature data concerning reactions of
heterocyclization of aminoazoles and demonstrates the application of these types of …
heterocyclization of aminoazoles and demonstrates the application of these types of …
3-Formylpyrazolo[1,5-a]pyrimidines as Key Intermediates for the Preparation of Functional Fluorophores
A one-pot route for the regioselective synthesis of 3-formylpyrazolo [1, 5-a] pyrimidines 4a–k
in good yields through a microwave-assisted process is provided. The synthesis proceeds …
in good yields through a microwave-assisted process is provided. The synthesis proceeds …
Synthesis and biological evaluation of novel pyrazolopyrimidines derivatives as anticancer and anti-5-lipoxygenase agents
A Rahmouni, S Souiei, MA Belkacem, A Romdhane… - Bioorganic …, 2016 - Elsevier
A novel series of 6-aryl-3-methyl-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4 (5H)-ones 3a-h
were synthesized in a single step via condensation of carboxamide 2 with some aromatic …
were synthesized in a single step via condensation of carboxamide 2 with some aromatic …
Recent synthetic methodologies for pyrazolo[1,5-a]pyrimidine
The development of new synthetic routes towards pyrazolo [1, 5-a] pyrimidines for their
biological and medicinal exploration is an attractive area for researchers. This review …
biological and medicinal exploration is an attractive area for researchers. This review …
Formation of nitrogen-containing six-membered heterocycles on steroidal ring system: A review
K Sharma, H Kumar - Steroids, 2023 - Elsevier
Steroidal heterocyclic compounds constitute interesting and promising scaffolds for drug
discovery as they have displayed diverse chemical reactivity and several types of biological …
discovery as they have displayed diverse chemical reactivity and several types of biological …
[PDF][PDF] Exploration of the chemistry and biological properties of pyrimidine as a privilege pharmacophore in therapeutics
The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring
compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin …
compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin …
Regioselective Synthesis of 7-(Trimethylsilylethynyl)pyrazolo[1,5-a]pyrimidines via Reaction of Pyrazolamines with Enynones
P Golubev, EA Karpova, AS Pankova… - The Journal of …, 2016 - ACS Publications
Condensation of enynones readily available from cheap starting material with
pyrazolamines provides easy access to fluorescent 7-(trimethylsilylethynyl) pyrazolo [1, 5-a] …
pyrazolamines provides easy access to fluorescent 7-(trimethylsilylethynyl) pyrazolo [1, 5-a] …
Synthesis of two novel pyrazolo [1, 5-a] pyrimidine compounds with antibacterial activity and biophysical insights into their interactions with plasma protein
LL He, Q Qi, X Wang, Y Li, Y Zhu, XF Wang, L Xu - Bioorganic Chemistry, 2020 - Elsevier
Two novel water-soluble pyrazolo [1, 5-a] pyrimidine derivatives, 5-chloro-7-(4-methyl-
piperazin− 1-yl)-pyrazolo [1, 5-a] pyrimidine (CMPS) and N′-(5-chloro-pyrazolo [1, 5-a] …
piperazin− 1-yl)-pyrazolo [1, 5-a] pyrimidine (CMPS) and N′-(5-chloro-pyrazolo [1, 5-a] …
Heterocyclic steroids: Synthetic routes and biological characteristics of steroidal fused bicyclic pyrimidines
Natural steroids are characterized as a vital class of compounds, a type of secondary
metabolites and components of cell membranes that widely accessible in plants or animals …
metabolites and components of cell membranes that widely accessible in plants or animals …