Insights into the medicinal chemistry of heterocycles integrated with a pyrazolo [1, 5-a] pyrimidine scaffold

MM Hammouda, HE Gaffer, KM Elattar - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Pyrazolo [1, 5-a] pyrimidines are the dominant motif of many drugs; for instance, zaleplon
and indiplon are sedative agents and ocinaplon was identified as an anxiolytic agent. The …

Aminoazole-based diversity-oriented synthesis of heterocycles

MV Murlykina, AD Morozova, IM Zviagin… - Frontiers in …, 2018 - frontiersin.org
The comprehensive review contains the analysis of literature data concerning reactions of
heterocyclization of aminoazoles and demonstrates the application of these types of …

3-Formylpyrazolo[1,5-a]pyrimidines as Key Intermediates for the Preparation of Functional Fluorophores

JC Castillo, A Tigreros, J Portilla - The Journal of Organic …, 2018 - ACS Publications
A one-pot route for the regioselective synthesis of 3-formylpyrazolo [1, 5-a] pyrimidines 4a–k
in good yields through a microwave-assisted process is provided. The synthesis proceeds …

Synthesis and biological evaluation of novel pyrazolopyrimidines derivatives as anticancer and anti-5-lipoxygenase agents

A Rahmouni, S Souiei, MA Belkacem, A Romdhane… - Bioorganic …, 2016 - Elsevier
A novel series of 6-aryl-3-methyl-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4 (5H)-ones 3a-h
were synthesized in a single step via condensation of carboxamide 2 with some aromatic …

Recent synthetic methodologies for pyrazolo[1,5-a]pyrimidine

MA Salem, MH Helal, MA Gouda… - Synthetic …, 2019 - Taylor & Francis
The development of new synthetic routes towards pyrazolo [1, 5-a] pyrimidines for their
biological and medicinal exploration is an attractive area for researchers. This review …

Formation of nitrogen-containing six-membered heterocycles on steroidal ring system: A review

K Sharma, H Kumar - Steroids, 2023 - Elsevier
Steroidal heterocyclic compounds constitute interesting and promising scaffolds for drug
discovery as they have displayed diverse chemical reactivity and several types of biological …

[PDF][PDF] Exploration of the chemistry and biological properties of pyrimidine as a privilege pharmacophore in therapeutics

OO Ajani, JT Isaac, TF Owoeye, AA Akinsiku - Int. J. Biol. Chem, 2015 - core.ac.uk
The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring
compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin …

Regioselective Synthesis of 7-(Trimethylsilylethynyl)pyrazolo[1,5-a]pyrimidines via Reaction of Pyrazolamines with Enynones

P Golubev, EA Karpova, AS Pankova… - The Journal of …, 2016 - ACS Publications
Condensation of enynones readily available from cheap starting material with
pyrazolamines provides easy access to fluorescent 7-(trimethylsilylethynyl) pyrazolo [1, 5-a] …

Synthesis of two novel pyrazolo [1, 5-a] pyrimidine compounds with antibacterial activity and biophysical insights into their interactions with plasma protein

LL He, Q Qi, X Wang, Y Li, Y Zhu, XF Wang, L Xu - Bioorganic Chemistry, 2020 - Elsevier
Two novel water-soluble pyrazolo [1, 5-a] pyrimidine derivatives, 5-chloro-7-(4-methyl-
piperazin− 1-yl)-pyrazolo [1, 5-a] pyrimidine (CMPS) and N′-(5-chloro-pyrazolo [1, 5-a] …

Heterocyclic steroids: Synthetic routes and biological characteristics of steroidal fused bicyclic pyrimidines

KM Elattar, A El‐Mekabaty - Journal of Heterocyclic Chemistry, 2021 - Wiley Online Library
Natural steroids are characterized as a vital class of compounds, a type of secondary
metabolites and components of cell membranes that widely accessible in plants or animals …