Understanding the emergence of complex biochemical systems, such as protein translation,
is a great challenge. Although synthetic approaches can provide insight into the potential …

How Nature discovered genetic coding is a largely ignored question, yet the answer is key to
explaining the transition from biochemical building blocks to life. Other, related puzzles also …

Modern life requires the translation of genetic information–encoded by nucleic acids–into
proteins, which establishes the essential link between genotype and phenotype. During …

The ribosome brings 3′-aminoacyl-tRNA and 3′-peptidyl-tRNAs together to enable
peptidyl transfer by binding them in two major ways. First, their anticodon loops are bound to …

The world in which we live is homochiral. The ribose units that form the backbone of DNA
and RNA are all D‐configured and the encoded amino acids that comprise the proteins of all …

The prebiotic formation of RNA building blocks is well‐supported experimentally, yet the
emergence of sequence‐and structure‐specific RNA oligomers is generally attributed to …

Die Welt, in der wir leben, ist homochiral. Die Riboseeinheiten, die das Rückgrat von DNA
und RNA bilden, sind alle D‐konfiguriert, und die kodierten Aminosäuren, aus denen die …

Ribosomal translation at the origin of life requires controlled aminoacylation to produce
mono-aminoacyl esters of tRNAs. Herein, we show that transient annealing of short RNA …

Biological translation is a universal process taking place in the ribosome. It involves the
synthesis of a protein with a particular sequence from the information encoded in a …

Previous origin of life studies have demonstrated the presence of amino acids and
nucleotides in the same prebiotic milieu. In this study, we set out to understand the interplay …