Human accelerated regions (HARs) are the fastest-evolving sequences in the human
genome. When HARs were discovered in 2006, their function was mysterious due to scant …

Chimpanzees are the closest living relatives of humans. The divergence between human
and chimpanzee ancestors dates to approximately 6, 5–7, 5 million years ago. Genetic …

Gene regulation shapes the evolution of phenotypic diversity. We investigated the evolution
of liver promoters and enhancers in six primate species using ChIP-seq (H3K27ac and …

Although the continual expansion of the brain during primate evolution accounts for our
enhanced cognitive capabilities, the drivers of brain evolution have scarcely been explored …

What made us human? Gene expression changes clearly played a significant part in human
evolution, but pinpointing the causal regulatory mutations is hard. Comparative genomics …

Comparative genomics has revealed a class of non-protein-coding genomic sequences that
display an extraordinary degree of conservation between two or more organisms, regularly …

The evolution of mankind has constantly been influenced by the pathogens encountered.
The various populations of modern humans that ventured out of Africa adapted to different …

The transition of the sexual mode occurs widely in animal evolution. In Caenorhabditis
nematodes, androdioecy, a sexual polymorphism composed of males and hermaphrodites …

Understanding what makes us uniquely human is a long-standing question permeating
fields from genomics, neuroscience, and developmental biology to medicine. The discovery …

Transposable elements have made major evolutionary impacts on creation of primate-
specific and human-specific genomic regulatory loci and species-specific genomic …