Epithelial‐to‐mesenchymal transition (EMT) is implicated in a wide array of malignant
behaviors of cancers, including proliferation, invasion, and metastasis. Most notably, previou …

The transforming growth factor (TGF)-β signaling events are well known to control diverse
processes and numerous responses, such as cell proliferation, differentiation, apoptosis …

Target occupancy is often insufficient to elicit biological activity, particularly for RNA,
compounded by the longstanding challenges surrounding the molecular recognition of RNA …

Breast cancer remains the most prevalent cause of cancer mortality in woman worldwide
due to the metastatic process and therapy resistance. Resistance against cancer therapy is …

Therapy resistance can arise within tumor cells because of genetic or phenotypic changes
(intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment …

Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …

Small non-coding microRNAs (miRNAs) are instrumental in physiological processes, such
as proliferation, cell cycle, apoptosis, and differentiation, processes which are often …

Key elements of cancer progression towards metastasis are the biological actions of cancer
stem cells and stromal cells in the tumour microenvironment. Cross-communication between …

Breast cancer (BC) is the most common malignancy among women worldwide. Like many
other cancers, BC therapy is challenging and sometimes frustrating. In spite of the various …

Triple-negative breast cancer (TNBC) is the most aggressive, prevalent, and distinct subtype
of breast cancer characterized by high recurrence rates and poor clinical prognosis, devoid …