Covering: January 2013 to September 2018 Sulfur-containing natural products are a large
class of significant functional molecules. Many of these compounds exhibit potent biological …

The replacement of para-substituted benzenes with saturated bi-and polycyclic bioisosteres–
bicyclo [1.1. 1] pentane, bicyclo [2.2. 2] octane and cubane,–often increases the potency …

Cubane is a highly strained saturated hydrocarbon system that has historically been of
interest in theoretical organic chemistry. More recently it has become a molecule of interest …

This Minireview focuses on selected topics in the syntheses of bicyclo [1.1. 1] pentane (BCP)
analogues. A brief historical introduction was included. The content covers various synthetic …

With a number of antibody–drug conjugates (ADCs) approved for clinical use as targeted
cancer therapies and numerous candidates in clinical trials, the field of ADCs is emerging as …

Total synthesis is considered by many as the finest combination of art and science. During
the last decades, several concepts were proposed for achieving the perfect vision of total …

Covering: 1970 to 2020 By definition total synthesis is the art and science of making the
molecules of living Nature in the laboratory, and by extension, their analogues. Although …

Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective
synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide …

Currently, four antibody-drug conjugates (ADCs) are approved by the Food and Drug
Administration or the European Medicine Agency to treat cancer patients. More than 60 …

Bioanalysis of complex biotherapeutics, such as antibody-drug conjugates (ADCs), is
challenging and requires multiple assays to describe their pharmacokinetic (PK) profiles. To …