Considering the lack of a comprehensive, multi-faceted overview of the ketogenic diet (KD)
in relation to health issues, we compiled the evidence related to the use of the ketogenic diet …

The prevalence of obesity, of type 2 diabetes mellitus (T2DM), and of cancer are all
increasing globally. The relationships between these diseases are complex, and thus …

Tumor cells may adapt to metabolic challenges by alternating between glycolysis and
oxidative phosphorylation (OXPHOS). To target this metabolic plasticity, we combined …

Background In preclinical work and retrospective population studies, the anti-diabetic drug
metformin has been associated with antineoplastic activity and decreased burden of many …

Most tumors display oncogene-driven reprogramming of several metabolic pathways, which
are crucial to sustain their growth and proliferation. In recent years, both dietary and …

Obesity is associated with a range of health outcomes that are of clinical and public health
significance, including cancer. Herein, we summarize epidemiologic and preclinical …

Cancer stem cells (CSCs) are an uncommon subset of tumor cells capable of self-renewal,
differentiating, and recreating the parental tumor when transplanted into the murine …

Biguanides are a class of antidiabetic drugs that includes phenformin and metformin;
however, the former was withdrawn from approval in many countries due to its toxicity …

Obesity leads to many diseases including hypercholesterolemia, type-2 diabetes,
hypertension, cardiovascular disease, and cancer. It is the fastest-growing lethal disease in …

The development of a single immuno-metabolic adjuvant capable of modulating, in the
appropriate direction and intensity, the complex antagonistic and symbiotic interplays …