Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius
var. Caesius and belongs to the anthracyclines family. The anti-cancer activity of Dox is …

Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies;
however, patients can experience cardiotoxic effects and this has limited the use of this …

Oxidative stress and cardiomyocyte apoptosis play critical roles in doxorubicin (DOX)-
induced cardiotoxicity. Previous studies indicated that fibronectin type III domain-containing …

Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment.
Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle …

Drug-induced cardiotoxicity has become one of the most common and detrimental health
concerns, which causes significant loss to public health and drug resources. Cannabinoid …

Doxorubicin (Dox) is a commonly used anthracycline chemotherapy with a side effect of
cardiotoxicity, which may increase the risk of heart failure for cancer patients. Although …

The utility of anthracycline antineoplastic agents in the clinic is compromised by the risk of
cardiotoxicity. It has been calculated that approximately 10% of patients treated with …

Doxorubicin (DOX) is an anticancer anthracycline that presents a dose‐dependent and
cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have …

The anthracycline doxorubicin (DOX) is widely used in chemotherapy due to its efficacy in
fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers …

Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …