Xenobiotics are converted by cytochrome P450 (CYP450) into highly reactive metabolites
(RMs) that covalently bind to the catalytic site of the enzyme itself, subsequently causing …

New phenylethylamine derivatives are among the most commonly abused new
psychoactive substances. They are synthesized and marketed in lieu of classical …

With the increasing prevalence of cardiovascular disease and associated disorders globally,
there has been a proliferation of medications for antiplatelet therapy, dyslipidemia, glycemic …

Background A pharmacovigilance database of real-world adverse drug reaction (ADR)
reports is helpful for characterising adverse events and identifying new signals after drug …

Background Intravenous (IV) amiodarone may be associated with liver injury that may
necessitate drug discontinuation. The prediction of amiodarone induced liver injury (AILI) …

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The case is reported of a 39-year-old severely obese woman who developed acute
metabolic disorders after the administration of a short course of intravenous amiodarone …

Mitochondrial dysfunction is a major mechanism whereby different drugs can induce liver
injury such as cytolytic hepatitis, microvesicular and/or macrovacuolar steatosis …

DISCUSSION Despite its ubiquitous and clinically important role as a central antiarrhythmic
agent, amiodarone's significant toxicity and side effect profile represent a considerable …

DISCUSSION* Postoperative arrhythmias may occur in as many as 25% of patients
undergoing cardiac surgery, 1 3% of patients undergoing noncardiac surgery, 2 and are …