Recent advances in mass spectrometry (MS)-based proteomics have enabled tremendous
progress in the understanding of cellular mechanisms, disease progression, and the …

According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Mass spectrometry is unmatched in its versatility for studying practically any aspect of the
proteome. Because the foundations of mass spectrometry-based proteomics are complex …

Abstract Background SARS-CoV-2 causes COVID-19 which has a widely diverse disease
profile. The mechanisms underlying its pathogenicity remain unclear. We set out to identify …

Proteomics research routinely involves identifying peptides and proteins via MS/MS
sequence database search. Thus the database search engine is an integral tool in many …

ProLuCID, a new algorithm for peptide identification using tandem mass spectrometry and
protein sequence databases has been developed. This algorithm uses a three tier scoring …

Cellular processes often depend on stable physical associations between proteins. Despite
recent progress, knowledge of the composition of human protein complexes remains limited …

Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of
incredible specificity in transmitting signals involved in cellular function, including germ cell …

Alternative splicing is pivotal to the regulation of gene expression and protein diversity in
eukaryotic cells. The detection of alternative splicing events requires specific omics …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …