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[HTML][HTML] Standards and guidelines for the interpretation and reporting of sequence variants in cancer: a joint consensus recommendation of the Association for …
Widespread clinical laboratory implementation of next-generation sequencing–based
cancer testing has highlighted the importance and potential benefits of standardizing the …
cancer testing has highlighted the importance and potential benefits of standardizing the …
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma …
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma …
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
Genome editing holds promise for correcting pathogenic mutations. However, it is difficult to
determine off-target effects of editing due to single-nucleotide polymorphism in individuals …
determine off-target effects of editing due to single-nucleotide polymorphism in individuals …
Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been
systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients …
systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients …
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling
The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an
individual patient presents a challenging clinical scenario. Furthermore, the molecular basis …
individual patient presents a challenging clinical scenario. Furthermore, the molecular basis …
[HTML][HTML] Tracking cancer evolution reveals constrained routes to metastases: TRACERx renal
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes
that have not been systematically studied to date. Here, we analyzed 575 primary and 335 …
that have not been systematically studied to date. Here, we analyzed 575 primary and 335 …
Bifrost: highly parallel construction and indexing of colored and compacted de Bruijn graphs
Memory consumption of de Bruijn graphs is often prohibitive. Most de Bruijn graph-based
assemblers reduce the complexity by compacting paths into single vertices, but this is …
assemblers reduce the complexity by compacting paths into single vertices, but this is …
Dissecting the causal mechanism of X-linked dystonia-parkinsonism by integrating genome and transcriptome assembly
Summary X-linked Dystonia-Parkinsonism (XDP) is a Mendelian neurodegenerative
disease that is endemic to the Philippines and is associated with a founder haplotype. We …
disease that is endemic to the Philippines and is associated with a founder haplotype. We …
A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects
Cytosine base editors (CBEs) offer a powerful tool for correcting point mutations, yet their
DNA and RNA off-target activities have caused concerns in biomedical applications. We …
DNA and RNA off-target activities have caused concerns in biomedical applications. We …