Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …

Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …

Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in
the plant defence system against water loss and pathogens. Nowadays these triterpenoids …

Hydrogel-forming microarray patches (HF-MAPs) are used to circumvent the skin barrier and
facilitate the noninvasive transdermal delivery of many hydrophilic substances. However …

Discovery of several poorly water soluble drugs in the past decade has led to the constant
need of develo** a novel dosage form which increases the solubility of these drug. They …

Paclitaxel and rapamycin have been reported to act synergistically to treat breast cancer.
Albeit paclitaxel is available for breast cancer treatment, the most commonly used …

Solid dispersion has been a topic of interest in recent years for its potential in improving oral
bioavailability, especially for poorly water soluble drugs where dissolution could be the rate …

Background and Purpose The traditional Chinese medicine, diosgenin (Dio), has attracted
increasing attention because it possesses various therapeutic effects, including anti-tumor …

Curcumin, the main bioactive polyphenolic compound in Curcuma longa L. rhizomes has a
wide range of bioactive properties. Curcumin presents low solubility in water and thus …

Ursolic acid (UA) is a naturally occurring triterpene that has been investigated for its
antitumor activity. However, its lipophilic character hinders its oral bioavailability, and …