One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that
include the methionine and folate cycles that are central to cellular function, providing 1C …

Neural tube defects (NTDs) are common birth defects and contribute to life-long disabilities,
high medical care costs, and perinatal and child mortality. This review is a primer on …

Neural tube defects (NTDs) are associated with substantial mortality, morbidity, disability,
and psychological and economic costs. Many are preventable with folic acid, and access to …

Neural tube defects (NTDs) are the second most common congenital malformations in
humans affecting the development of the central nervous system. Although NTD …

Decisions about the use of psychotropic medication in pregnancy are an ongoing challenge
for clinicians and women with mental health problems, owing to the uncertainties around …

Anemia of pregnancy, an important risk factor for fetal and maternal morbidity, is considered
a global health problem, affecting almost 50% of pregnant women. In this article, diagnosis …

With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between
1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk. Therefore, folic …

Background Surveillance of congenital anomalies is important to identify potential
teratogens. Methods This study analysed the prevalence of 61 congenital anomaly …

Objective To validate the estimates of Global Burden of Disease (GBD) due to congenital
anomaly for Europe by comparing infant mortality data collected by EUROCAT registries …

Background China implemented a partial two-child policy (2013) followed by a universal two-
child policy (2015), replacing the former one-child policy mandated by the government. The …