Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Abstract Purpose of Review Cardiovascular diseases are the leading cause of death
worldwide, largely due to the limited regenerative capacity of the adult human heart. In …

Wnt signalling is essential for regulation of embryonic development and adult tissue
homeostasis,–, and aberrant Wnt signalling is frequently associated with cancers. Wnt …

Wnts are evolutionarily conserved ligands that signal at short range to regulate
morphogenesis, cell fate, and stem cell renewal. The first and essential steps in Wnt …

Intercellular communication by Wnt proteins governs many essential processes during
development, tissue homeostasis and disease in all metazoans. Many context-dependent …

Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles
in development and homeostasis. Post-translational modifications of Wnts regulate their …

Wnt signaling is essential for normal development and is a therapeutic target in cancer. The
enzyme PORCN, or porcupine, is a membrane-bound O-acyltransferase (MBOAT) that is …

Wnt signaling pathway plays indispensable roles in embryonic development and adult
tissue homeostasis. However, the regulatory mechanisms involved in Wnt ligand trafficking …

Introduction Liver fibrosis is a significant global health burden that lacks effective therapies. It
can progress to cirrhosis and hepatocellular carcinoma (HCC). Aberrant hedgehog pathway …

Non-alcoholic steatohepatitis (NASH) is characterized by liver inflammation, fat
accumulation, and collagen deposition. Due to the limited availability of effective treatments …