Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Ferroptosis is a recently discovered form of regulated cell death that is morphologically,
genetically, and biochemically distinct from apoptosis and necroptosis, and its potential use …

Glioblastoma (GBM) is characterized by exceptionally high intratumoral heterogeneity.
However, the molecular mechanisms underlying the origin of different GBM cell populations …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

Tumor acidity is one of the cancer hallmarks and is associated with metabolic
reprogramming and the use of glycolysis, which results in a high intracellular lactic acid …

Tumors have long been known to rewire their metabolism to endorse their proliferation,
growth, survival, and invasiveness. One of the common characteristics of these alterations is …

The tumor microenvironment (TME) in ovarian cancer (OC) has much greater complexity
than previously understood. In response to aggressive pro-angiogenic stimulus, blood …

Hypoxia and elevated extracellular acidification are prevalent features of solid tumors and
they are often shown to facilitate cancer progression and drug resistance. In this review, we …