Radiotherapy resistance: identifying universal biomarkers for various human cancers

I Larionova, M Rakina, E Ivanyuk, Y Trushchuk… - Journal of cancer …, 2022 - Springer
Radiotherapy (RT) is considered as a standard in the treatment of most solid cancers,
including glioblastoma, lung, breast, rectal, prostate, colorectal, cervical, esophageal, and …

The emerging roles of ATP-dependent chromatin remodeling complexes in pancreatic cancer

N Hasan, N Ahuja - Cancers, 2019 - mdpi.com
Pancreatic cancer is an aggressive cancer with low survival rates. Genetic and epigenetic
dysregulation has been associated with the initiation and progression of pancreatic tumors …

Knockdown of circ_0006528 suppresses cell proliferation, migration, invasion, and adriamycin chemoresistance via regulating the miR-1236-3p/CHD4 axis in breast …

J Hao, X Du, F Lv, Q Shi - Journal of Surgical Research, 2021 - Elsevier
Background Adriamycin (ADM) is one of the postoperative chemotherapy drugs for breast
cancer (BCa) patients. Circular RNAs have been shown to modulate ADM resistance in …

CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents

Y Oyama, S Shigeta, H Tokunaga, K Tsuji… - PLoS …, 2021 - journals.plos.org
Platinum sensitivity is an important prognostic factor in patients with ovarian cancer.
Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a core member of the …

The epigenetic factor CHD4 contributes to metastasis by regulating the EZH2/β-catenin axis and acts as a therapeutic target in ovarian cancer

J Wang, F Zhong, J Li, H Yue, W Li, X Lu - Journal of Translational …, 2023 - Springer
Background The overall survival rate of patients with advanced ovarian cancer (OC) has
remained static for several decades. Advanced ovarian cancer is known for its poor …

[HTML][HTML] CHD4 mediates SOX2 transcription through TRPS1 in luminal breast cancer

J Zhang, X Lv, B Wei, X Gong, L Chen - Cellular Signalling, 2022 - Elsevier
Chromodomain helicase DNA binding protein 4 (CHD4), as a core component of the
nucleosome remodeling and deactetylase (NuRD) complex, participated in the inititation …

[HTML][HTML] CHD4 as an important mediator in regulating the malignant behaviors of colorectal cancer

CL Chang, CR Huang, SJ Chang, CC Wu… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) has ranked first in terms of incidence in Taiwan. Surgical resection
combined with chemo-, radio-, or targeted-therapies are the main treatments for CRC …

[HTML][HTML] Correlation between mismatch repair statuses and the prognosis of stage I–IV colorectal cancer

G Tong, G Zhang, Y Hu, X Xu, Y Wang - Frontiers in oncology, 2024 - frontiersin.org
Background The role of microsatellite instability (MSI) and prognosis for stage II–III colorectal
cancer (CRC) has been described, but the role of MSI in stage I and IV CRC is controversial …

High expression of VSTM2L induced resistance to chemoradiotherapy in rectal cancer through downstream IL‐4 signaling

H Liu, Z Zhang, P Zhen, M Zhou - Journal of immunology …, 2021 - Wiley Online Library
Background. Preoperative chemoradiotherapy (pCRT) is a common and essential
therapeutic strategy for patients with locally advanced rectal cancer (LARC), but poor tumor …

CHD4 acts as a prognostic factor and drives radioresistance in HPV negative HNSCC

F Geyer, M Geyer, U Reuning, S Klapproth, KD Wolff… - Scientific Reports, 2024 - nature.com
Despite great efforts in improving existing therapies, the outcome of patients with advanced
radioresistant HPV-negative head and neck squamous cell carcinoma (HNSCC) remains …