Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

The proglucagon gene (glu) encodes glucagon, expressed in pancreatic islets, and the
insulinotropic hormone GLP-1, expressed in the intestines. These two hormones exert …

Discovered almost simultaneously with insulin, glucagon is a pleiotropic hormone with
metabolic action that goes far beyond its classical role to increase blood glucose. Albeit best …

Since the relationship between TCF7L2 (also known as TCF-4) polymorphisms and type 2
diabetes mellitus was identified in 2006, extensive genome-wide association examinations …

The WNT signalling pathway is involved in many physiological and pathophysiological
activities. WNT ligands bind to Frizzled receptors and co-receptors (LDL receptor-related …

The role of the Wnt signaling pathway in metabolic homeostasis has drawn our intensive
attention, especially after the genome-wide association study discovery that certain …

The bipartite transcription factor β-catenin/TCF (cat/TCF) has been recognized as the major
effector of the Wnt signaling pathway for more than a decade, and its over-activation has …

The Wnt signaling pathway has recently been demonstrated to play an important role in
bone cell function. In previous studies using DNA microarray analyses, we observed a …

Synthetic glucagon-like peptide-1 (GLP-1) analogues are effective anti-obesity and anti-
diabetes drugs. The beneficial actions of GLP-1 go far beyond insulin secretion and …