Protozoan parasites continue to cause a significant health and economic burden worldwide.
As infectious organisms, they pose unique and difficult challenges due to a level of …

At first glance the nucleus is a highly conserved organelle. Overall nuclear morphology, the
octagonal nuclear pore complex, the presence of peripheral heterochromatin and the …

Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

Trypanosomatids are eukaryotic parasites exhibiting polycistronic transcription and trans-
splicing. Post-transcriptional mechanisms are acknowledged as pivotal in gene expression …

Trypanosoma cruzi is the etiological agent of Chagas disease and a peculiar eukaryote with
unique biological characteristics. DNA damage can block RNA polymerase, activating …

Parasites are the leading causes of morbidity and mortality in both humans and animals,
imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has …

Epigenetic marks enable cells to acquire new biological features that favor their adaptation
to environmental changes. These marks are chemical modifications on chromatin …

Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

Post‐translational methylation of proteins, which occurs in arginines and lysines, modulates
several biological processes at different levels of cell signaling. Recently, methylation has …

In all domains of life, transfer (t) RNAs can be interrupted by intervening sequences (introns),
which must be removed by splicing to generate mature molecules required for protein …