Hypoxia tolerance, nitric oxide, and nitrite: lessons from extreme animals

A Fago, FB Jensen - Physiology, 2015 - journals.physiology.org
Among vertebrates able to tolerate periods of oxygen deprivation, the painted and red-eared
slider turtles (Chrysemys picta and Trachemys scripta) and the crucian carp (Carassius …

Metabolic adaptations to anoxia and reoxygenation: New lessons from freshwater turtles and crucian carp

A Bundgaard, IM Ruhr, A Fago, GLJ Galli - Current Opinion in Endocrine …, 2020 - Elsevier
As the final electron acceptor in the electron transport chain, oxygen is vital to produce ATP
in the process of oxidative phosphorylation. In most vertebrates, the absence of oxygen …

Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury

A Bundgaard, AM James, AV Gruszczyk, J Martin… - Scientific reports, 2019 - nature.com
ATP depletion and succinate accumulation during ischemia lead to oxidative damage to
mammalian organs upon reperfusion. In contrast, freshwater turtles survive weeks of anoxia …

Physiological ecology of overwintering in hatchling turtles

JP Costanzo, RE Lee Jr… - Journal of Experimental …, 2008 - Wiley Online Library
Temperate species of turtles hatch from eggs in late summer. The hatchlings of some
species leave their natal nest to hibernate elsewhere on land or under water, whereas …

Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia

A Bundgaard, K Qvortrup… - Journal of …, 2019 - journals.biologists.com
Mitochondria are important to cellular homeostasis, but can become a dangerous liability
when cells recover from hypoxia. Anoxia-tolerant freshwater turtles show reduced …

Cardiovascular responses to limiting oxygen levels

JAW Stecyk - Fish physiology, 2017 - Elsevier
The capacity for metabolic energy (adenosine triphosphate, ATP) production via oxidative
phosphorylation is much greater (~ 15×) than by anaerobic glycolysis, and vertebrates have …

The role of Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion-dependent regulation of MAPKERK: Discordant proteomic effect of MAPKp38

JJ Haddad - Protein and Peptide Letters, 2007 - ingentaconnect.com
Background: The molecular regulation of MAPKs and apoptosis was investigated in a model
of hypoxiatolerance. Survival of neurons in Chrysemys picta bellii, an anoxia-tolerant turtle …

Effect of temperature and prolonged anoxia exposure on electrophysiological properties of the turtle (Trachemys scripta) heart

JAW Stecyk, V Paajanen, AP Farrell… - American Journal of …, 2007 - journals.physiology.org
Cardiac activity of the turtle (Trachemys scripta) is greatly depressed with cold acclimation
and anoxia. We examined what electrophysiological modifications accompany and perhaps …

New Insights to Regulation of Fructose-1,6-bisphosphatase during Anoxia in Red-Eared Slider, Trachemys scripta elegans

A Gupta, A Varma, KB Storey - Biomolecules, 2021 - mdpi.com
The red-eared slider (Trachemys scripta elegans) undergoes numerous changes to its
physiological and metabolic processes to survive without oxygen. During anoxic conditions …

Lactate metabolism in anoxic turtles: an integrative review

DE Warren, DC Jackson - Journal of Comparative Physiology B, 2008 - Springer
Painted turtles can accumulate lactic acid to extremely high concentrations during long-term
anoxic submergence, with plasma lactate exceeding 200 mmol l− 1. The aims of this review …