Peptides and protein hydrolysates exhibiting anti-inflammatory activity: Sources, structural features and modulation mechanisms

J Rivera-Jiménez, C Berraquero-García… - Food & Function, 2022 - pubs.rsc.org
Inflammation is the response of the immune system to harmful stimuli such as tissue injury,
infection or toxic chemicals, which has the aim of eliminating irritants or pathogenic …

Marine organisms as a rich source of biologically active peptides

MWFS Macedo, NB Cunha, JA Carneiro… - Frontiers in Marine …, 2021 - frontiersin.org
Oceanic environments are one of the largest sources of bioactive molecules, due to the high
degree of biodiversity and the innumerable ecological relationships established between …

Natural products acting against S. aureus through membrane and cell wall disruption

G Kumar, K Engle - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several
community and hospital-acquired infections with life-threatening complications such as …

Accelerating the discovery and design of antimicrobial peptides with artificial intelligence

MC Aguilera-Puga, NL Cancelarich, MM Marani… - … drug discovery and …, 2023 - Springer
Peptides modulate many processes of human physiology targeting ion channels, protein
receptors, or enzymes. They represent valuable starting points for the development of new …

In silico and in vitro analyses reveal promising antimicrobial peptides from myxobacteria

BS Arakal, DE Whitworth, PE James… - Probiotics and …, 2023 - Springer
Antimicrobial resistance (AMR) is a global concern, and as soon as new antibiotics are
introduced, resistance to those agents emerges. Therefore, there is an increased appetite for …

Release of immunomodulatory peptides at bacterial membrane interfaces as a novel strategy to fight microorganisms

TV de Freitas, U Karmakar, AG Vasconcelos… - Journal of Biological …, 2023 - jbc.org
Cationic and amphiphilic peptides can be used as homing devices to accumulate
conjugated antibiotics to bacteria-enriched sites and promote efficient microbial killing …

Antimicrobial peptides designed by computational analysis of proteomes

D Monsalve, A Mesa, LM Mira, C Mera, S Orduz… - Antonie van …, 2024 - Springer
Antimicrobial peptides (AMPs) are promising cationic and amphipathic molecules to fight
antibiotic resistance. To search for novel AMPs, we applied a computational strategy to …

Neuroprotective effects on microglia and insights into the structure–activity relationship of an antioxidant peptide isolated from Pelophylax perezi

A Plácido, C do Pais do Amaral… - Journal of Cellular …, 2022 - Wiley Online Library
Tryptophyllins constitute a heterogeneous group of peptides that are one of the first classes
of peptides identified from amphibian's skin secretions. Here, we report the structural …

[HTML][HTML] Schistocins: Novel antimicrobial peptides encrypted in the Schistosoma mansoni Kunitz Inhibitor SmKI-1

BPO Santos, ESF Alves, CS Ferreira… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Here we describe a new class of cryptides (peptides encrypted within a larger
protein) with antimicrobial properties, named schistocins, derived from SmKI-1, a key protein …

Occurrence and evolutionary conservation analysis of α‐helical cationic amphiphilic segments in the human proteome

ISD Costa, T Junot, FL Silva, W Felix… - The FEBS …, 2024 - Wiley Online Library
The existence of encrypted fragments with antimicrobial activity in human proteins has been
thoroughly demonstrated in the literature. Recently, algorithms for the large‐scale …