Electrochemical methods for the analysis of clinically relevant biomolecules

M Labib, EH Sargent, SO Kelley - Chemical reviews, 2016 - ACS Publications
Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …

Recent advances in potentiometric biosensors

J Ding, W Qin - TrAC Trends in Analytical Chemistry, 2020 - Elsevier
Potentiometry based on ion-selective electrodes (ISEs) has been injected with new vigor
and gone through a renaissance with the improvements in the detection limits and …

CRISPR/Cas13a‐powered electrochemical microfluidic biosensor for nucleic acid amplification‐free miRNA diagnostics

R Bruch, J Baaske, C Chatelle, M Meirich… - Advanced …, 2019 - Wiley Online Library
Noncoding small RNAs, such as microRNAs, are becoming the biomarkers of choice for
multiple diseases in clinical diagnostics. A dysregulation of these microRNAs can be …

Light-activated CRISPR-Cas12a for amplified imaging of microRNA in cell cycle phases at single-cell levels

H Liu, J Dong, Z Duan, F **a, I Willner, F Huang - Science Advances, 2024 - science.org
An ortho-nitrobenzyl phosphate ester–caged nucleic acid hairpin structure coupled to the
CRISPR-Cas12a complex is introduced as a functional reaction module for the light-induced …

Specific miRNA disease biomarkers in blood, serum and plasma: challenges and prospects

C Backes, E Meese, A Keller - Molecular diagnosis & therapy, 2016 - Springer
Significant effort has been devoted to discovering microRNA (miRNA) disease biomarkers.
In particular, miRNAs in whole blood or specific blood components are candidates for …

microRNA biosensors: Opportunities and challenges among conventional and commercially available techniques

T Kilic, A Erdem, M Ozsoz, S Carrara - Biosensors and Bioelectronics, 2018 - Elsevier
As being the most extensively studied, non-coding, evolutionary conserved, post-
transcriptional gene regulators of genome, microRNAs (miRNAs) have taken great attention …

Smartphone-based portable electrochemical biosensing system for detection of circulating microRNA-21 in saliva as a proof-of-concept

SS Low, Y Pan, D Ji, Y Li, Y Lu, Y He, Q Chen… - Sensors and Actuators B …, 2020 - Elsevier
Circulating microRNAs (miRNAs) are effective cancer biomarkers that are highly stable in
body fluids enabling noninvasive detection. Portable, low-cost and efficient biosensing …

[HTML][HTML] Novel and simple electrochemical biosensor monitoring attomolar levels of miRNA-155 in breast cancer

AR Cardoso, FTC Moreira, R Fernandes… - Biosensors and …, 2016 - Elsevier
This work, describes for the first time, a simple biosensing design to yield an ultrasensitive
electrochemical biosensor for a cancer biomarker detection, miRNA-155, with linear …

Ferrocene-functionalized covalent organic frameworks and target catalyzed hairpin assembly strategy for amplified electrochemical determination of microRNAs

S Feng, Y Xue, J Huang, X Yang - Analytical Chemistry, 2022 - ACS Publications
MicroRNAs (miRNAs) are considered as significant biomarkers in early diagnosis and
treatment of diseases. Herein, an electrochemical biosensor that uses ferrocene (Fc) …

Molecular biomarkers of depression

A Gururajan, G Clarke, TG Dinan, JF Cryan - … & Biobehavioral Reviews, 2016 - Elsevier
Depression is the leading psychiatric disorder worldwide with a significant economic and
emotional strain on society. There is a need for robust biomarkers which will help improve …