Summary We searched MEDLINE, Embase, CINAHL, AMED and CENTRAL databases until
December 2014 and included 133 randomised controlled trials of peri‐operative gabapentin …

Background Perioperative pain treatment often consist of combinations of non‐opioid and
opioid analgesics,'multimodal analgesia', in which gabapentin is currently used. The aim …

Objective: Gabapentin (GBP) is an anticonvulsant medication that is also used to treat
restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed …

Background Anxiety in relation to surgery is a well‐known problem. Melatonin offers an
alternative treatment to benzodiazepines for ameliorating this condition in the preoperative …

Objective: Gabapentin is commonly used off-label in the treatment of psychiatric disorders
with success, failure, and controversy. A systematic review of the literature was performed to …

Melatonin (MLT) has been implicated in several pathophysiological states, including pain.
MLT mostly activates two G-protein coupled receptors, MT1 and MT2. In this review, we …

In the past few years possible mechanisms that link diabetes and depression have been
found. One of these mechanisms is the increase in lipid peroxidation and decrease in …

Background Surgery is one of the stressors that cause physiological and psychological
stress. Anxiety and pain and their complications are very important in anesthesiology and …

Previous systematic reviews and meta-analyses of randomized controlled trials have
reported controversial findings regarding the effects of melatonin on pain reduction. The aim …

Melatonin is an important hormone for regulating mammalian circadian biology and cellular
homeostasis. Recent evidence has shown that melatonin exerts anti-nociception effects in …