Microneedles for drug and vaccine delivery

YC Kim, JH Park, MR Prausnitz - Advanced drug delivery reviews, 2012 - Elsevier
Microneedles were first conceptualized for drug delivery many decades ago, but only
became the subject of significant research starting in the mid-1990's when microfabrication …

A comprehensive review of microneedles: Types, materials, processes, characterizations and applications

FK Aldawood, A Andar, S Desai - Polymers, 2021 - mdpi.com
Drug delivery through the skin offers many advantages such as avoidance of hepatic first-
pass metabolism, maintenance of steady plasma concentration, safety, and compliance over …

Cryomicroneedles for transdermal cell delivery

H Chang, SWT Chew, M Zheng, DCS Lio… - Nature Biomedical …, 2021 - nature.com
Cell therapies for the treatment of skin disorders could benefit from simple, safe and efficient
technology for the transdermal delivery of therapeutic cells. Conventional cell delivery by …

Approaches for breaking the barriers of drug permeation through transdermal drug delivery

A Alexander, S Dwivedi, TK Giri, S Saraf, S Saraf… - Journal of controlled …, 2012 - Elsevier
Transdermal drug delivery system (TDDS) utilizes the skin as executable route for drug
administration but the foremost barrier against drug permeability is the stratum corneum and …

Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

AS Rzhevskiy, TRR Singh, RF Donnelly… - Journal of controlled …, 2018 - Elsevier
Microneedles is the technique of drug delivery enhancement, which was primarily designed
for facilitating percutaneous drug delivery. Started from the development of simple solid …

Microneedle patches as drug and vaccine delivery platform

J Li, M Zeng, H Shan, C Tong - Current medicinal chemistry, 2017 - ingentaconnect.com
Background: Transcutaneous delivery is the ideal method for delivering therapeutic
reagents or vaccines into skin. With their promise of self-administration, cost-effective and …

Microneedle patches for vaccination in develo** countries

J Arya, MR Prausnitz - Journal of Controlled Release, 2016 - Elsevier
Millions of people die of infectious diseases each year, mostly in develo** countries,
which could largely be prevented by the use of vaccines. While immunization rates have …

Progress in microneedle array patch (MAP) for vaccine delivery

TT Nguyen, Y Oh, Y Kim, Y Shin, SK Baek… - Human Vaccines & …, 2021 - Taylor & Francis
ABSTRACT A microneedle array patch (MAP) has been developed as a new delivery
system for vaccines. Preclinical and clinical trials with a vaccine MAP showed improved …

Emerging era of microneedle array for pharmaceutical and biomedical applications: recent advances and toxicological perspectives

S Dugam, R Tade, R Dhole, S Nangare - Future Journal of Pharmaceutical …, 2021 - Springer
Abstract Background Microneedles (MNs) are the utmost unique, efficient, and minimally
invasive inventions in the pharmaceutical field. Over the past decades, many scientists …

Recent advances in polymer microneedles for drug transdermal delivery: Design strategies and applications

R Wang, G Jiang, UE Aharodnikau… - Macromolecular …, 2022 - Wiley Online Library
In recent years, transdermal drug delivery based on microneedles (MNs) technology has
received extensive attention, which offers a safer and painless alternative to hypodermic …