The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

With the discovery of the incredible diversity of neurons, Cajal and coworkers laid the
foundation of modern neuroscience. Neuron types are not only structural units of nervous …

Three-dimensional (3D) digital brain atlases and high-throughput brain-wide imaging
techniques generate large multidimensional datasets that can be registered to a common …

To understand how the cerebellar cortex transforms mossy fiber (MF) inputs into Purkinje
cell (PC) outputs, it is vital to delineate the elements of this circuit. Candelabrum cells (CCs) …

The advancement of single-cell RNA-sequencing technologies has led to an explosion of
cell type definitions across multiple organs and organisms. While standards for data and …

We have previously established that PV+ neurons and Npas1+ neurons are distinct neuron
classes in the external globus pallidus (GPe): they have different topographical …

Consistent identification of neurons in different experimental modalities is a key problem in
neuroscience. Although methods to perform multimodal measurements in the same set of …

Recent advances in brain imaging allow producing large amounts of 3-D volumetric data
from which morphometry data is reconstructed and measured. Fine detailed structural …

Over the years, genetic studies have identified multiple genetic risk variants associated with
neurodegenerative disorders and helped reveal new biological pathways and genes of …

Pairwise map** of single-cell gene expression and electrophysiology in intact three-
dimensional (3D) tissues is crucial for studying electrogenic organs (eg, brain and heart) …