Enoyl acyl carrier protein reductase (InhA) is a key enzyme involved in fatty acid synthesis
mainly mycolic acid biosynthesis that is a part of NADH dependent acyl carrier protein …

The dormant phenotype of Mycobacterium tuberculosis that develops during infection poses
a major challenge in disease treatment, since these bacilli show tolerance to front-line …

Based on the molecular hybridization strategy, thirty-four imidazo [1, 2-a] pyridine amides
(IPAs) and imidazo [1, 2-a] pyridine sulfonamides (IPSs) were designed and synthesized …

Tuberculosis (TB) remains the major health problem causing morbidity and mortality
throughout the world. Increase in multidrug resistant, extensively drug-resistant, and totally …

The InhA inhibitors play key role in mycolic acid synthesis by preventing the fatty acid
biosynthesis pathway. In this present article, Pharmacophore modelling and molecular …

In the present contribution, multicomplex‐based pharmacophore studies were carried out on
the structural proteome of Plasmodium falciparum 1‐deoxy‐d‐xylulose‐5‐phosphate …

Drug resistance has made malaria an untreatable disease and therefore intensified the
need for the development of new drugs and the identification of potential drug targets. In this …

Caspase-1 is a key endoprotease responsible for the post-translational processing of pro-
inflammatory cytokines IL-1β, 18 & 33. Excessive secretion of IL-1β leads to numerous …

In the present work, multiple pharmacophore-based virtual screening of the SPECS natural
product database was carried out to identify novel inhibitors of the validated biological …

Tuberculosis (TB) is one of the leading causes of death worldwide. The development of new
anti-tubercular drugs is required as resistant strains of M. tuberculosis to various first-line …