Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …

Various surgical techniques and pharmaceutical treatments have been developed to
improve the current technologies of treating brain diseases. Focused ultrasound (FUS) is a …

Here, the results of a phase 1/2 single-arm trial (NCT03744026) assessing the safety and
efficacy of blood-brain barrier (BBB) disruption with an implantable ultrasound system in …

Purpose: The blood–brain barrier (BBB) limits the efficacy of drug therapies for glioblastoma
(GBM). Preclinical data indicate that low-intensity pulsed ultrasound (LIPU) can transiently …

The blood-brain barrier (BBB) limits the delivery of systemically administered drugs to the
brain. Methods to circumvent the BBB have been developed, but none are used in standard …

Pharmacological treatment of gliomas and other brain-infiltrating tumors remains
challenging due to limited delivery of most therapeutics across the blood–brain barrier …

Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is currently being
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …

The blood-brain barrier (BBB) restricts delivery of most chemotherapy agents to brain
tumors. Here, we investigated a clinical focused ultrasound (FUS) device to disrupt the BBB …

Introduction Glioblastoma (GBM) is the most common and aggressive primary brain cancer
in adults. Few cytotoxic chemotherapies have been shown to be effective against GBM, due …

Systemically administered chemotherapeutic drugs are often ineffective in the treatment of
invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of …