The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

Cellular uptake of nanoparticles: journey inside the cell

S Behzadi, V Serpooshan, W Tao, MA Hamaly… - Chemical society …, 2017 - pubs.rsc.org
Nanoscale materials are increasingly found in consumer goods, electronics, and
pharmaceuticals. While these particles interact with the body in myriad ways, their beneficial …

Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

J Mondal, S Pillarisetti, V Junnuthula, M Saha… - Journal of Controlled …, 2023 - Elsevier
Exosomes are endosome-derived nanovesicles involved in cellular communication. They
are natural nanocarriers secreted by various cells, making them suitable candidates for …

Pathways of antigen processing

JS Blum, PA Wearsch… - Annual review of …, 2013 - annualreviews.org
T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment …

F Sallusto, M Cella, C Danieli… - The Journal of …, 1995 - rupress.org
We have previously demonstrated that human peripheral blood low density mononuclear
cells cultured in granulocyte/macrophage colony-stimulating factor (GM-CSF) and …

Endocytosis

S Mukherjee, RN Ghosh… - Physiological …, 1997 - journals.physiology.org
Mammalian cells take up extracellular material by a variety of different mechanisms that are
collectively termed endocytosis. Endocytic mechanisms serve many important cellular …

Lipid-like materials for low-dose, in vivo gene silencing

KT Love, KP Mahon, CG Levins… - Proceedings of the …, 2010 - National Acad Sciences
Significant effort has been applied to discover and develop vehicles which can guide small
interfering RNAs (siRNA) through the many barriers guarding the interior of target cells …

Virus entry by endocytosis

J Mercer, M Schelhaas… - Annual review of …, 2010 - annualreviews.org
Although viruses are simple in structure and composition, their interactions with host cells
are complex. Merely to gain entry, animal viruses make use of a repertoire of cellular …

Macropinocytosis: an endocytic pathway for internalising large gulps

JP Lim, PA Gleeson - Immunology and cell biology, 2011 - Wiley Online Library
Macropinocytosis is a regulated form of endocytosis that mediates the non‐selective uptake
of solute molecules, nutrients and antigens. It is an actin‐dependent process initiated from …

C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

CA Ogden, A deCathelineau, PR Hoffmann… - The Journal of …, 2001 - rupress.org
Removal of apoptotic cells is essential for maintenance of tissue homeostasis,
organogenesis, remodeling, development, and maintenance of the immune system …