Microbial and animal rhodopsins: structures, functions, and molecular mechanisms

OP Ernst, DT Lodowski, M Elstner, P Hegemann… - Chemical …, 2014‏ - ACS Publications
Organisms of all domains of life use photoreceptor proteins to sense and respond to light.
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …

The multitalented microbial sensory rhodopsins

JL Spudich - Trends in microbiology, 2006‏ - cell.com
Sensory rhodopsins are photoactive, membrane-embedded seven-transmembrane helix
receptors that use retinal as a chromophore. They are widespread in the microbial world in …

Three-dimensional solid-state NMR study of a seven-helical integral membrane proton pump—structural insights

L Shi, MAM Ahmed, W Zhang, G Whited… - Journal of molecular …, 2009‏ - Elsevier
Proteorhodopsin (PR) is a recently discovered ubiquitous eubacterial retinal-binding light-
driven proton pump. Almost 1000 PR variants are widely distributed in species of marine …

A unique choanoflagellate enzyme rhodopsin exhibits light-dependent cyclic nucleotide phosphodiesterase activity

K Yoshida, SP Tsunoda, LS Brown, H Kandori - Journal of Biological …, 2017‏ - jbc.org
Photoactivated adenylyl cyclase (PAC) and guanylyl cyclase rhodopsin increase the
concentrations of intracellular cyclic nucleotides upon illumination, serving as promising …

[HTML][HTML] Eubacterial rhodopsins—unique photosensors and diverse ion pumps

LS Brown - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2014‏ - Elsevier
Since the discovery of proteorhodopsins, the ubiquitous marine light-driven proton pumps of
eubacteria, a large number of other eubacterial rhodopsins with diverse structures and …

Microbial rhodopsins: scaffolds for ion pumps, channels, and sensors

JP Klare, I Chizhov, M Engelhard - Bioenergetics: Energy Conservation …, 2007‏ - Springer
Microbial rhodopsins have been intensively researched for the last three decades. Since the
discovery of bacteriorhodopsin, the scope of microbial rhodopsins has been considerably …

Oligomeric structure of anabaena sensory rhodopsin in a lipid bilayer environment by combining solid-state NMR and long-range DEER constraints

S Milikisiyants, S Wang, RA Munro, M Donohue… - Journal of molecular …, 2017‏ - Elsevier
Oligomerization of membrane proteins is common in nature. Here, we combine spin-labeling
double electron–electron resonance (DEER) and solid-state NMR (ssNMR) spectroscopy to …

Three strategically placed hydrogen-bonding residues convert a proton pump into a sensory receptor

Y Sudo, JL Spudich - Proceedings of the National Academy of Sciences, 2006‏ - pnas.org
In haloarchaea, light-driven ion transporters have been modified by evolution to produce
sensory receptors that relay light signals to transducer proteins controlling motility behavior …

Eukaryotic G protein-coupled receptors as descendants of prokaryotic sodium-translocating rhodopsins

DN Shalaeva, MY Galperin, AY Mulkidjanian - Biology direct, 2015‏ - Springer
Microbial rhodopsins and G-protein coupled receptors (GPCRs, which include animal
rhodopsins) are two distinct (super) families of heptahelical (7TM) membrane proteins that …