Measuring the tail: Methods for poly (A) tail profiling

A Brouze, PS Krawczyk… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Abstract The 3′‐end poly (A) tail is an important and potent feature of most mRNA
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …

Determinants and implications of mRNA poly (A) tail size–does this protein make my tail look big?

AL Jalkanen, SJ Coleman, J Wilusz - Seminars in cell & developmental …, 2014 - Elsevier
While the phenomenon of polyadenylation has been well-studied, the dynamics of poly (A)
tail size and its impact on transcript function and cell biology are less well-appreciated. The …

Accessory subunits are integral for assembly and function of human mitochondrial complex I

DA Stroud, EE Surgenor, LE Formosa, B Reljic… - Nature, 2016 - nature.com
Complex I (NADH: ubiquinone oxidoreductase) is the first enzyme of the mitochondrial
respiratory chain and is composed of 45 subunits in humans, making it one of the largest …

Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice

X Jiang, Y Cheng, Y Zhu, C Xu, Q Li, X **ng… - Nature …, 2023 - nature.com
In mammals, the production of mature oocytes necessitates rigorous regulation of the
discontinuous meiotic cell-cycle progression at both the transcriptional and post …

Transcription dynamics regulate poly (A) tails and expression of the RNA degradation machinery to balance mRNA levels

B Slobodin, A Bahat, U Sehrawat, S Becker-Herman… - Molecular cell, 2020 - cell.com
Gene expression is regulated by the rates of synthesis and degradation of mRNAs, but how
these processes are coordinated is poorly understood. Here, we show that reduced …

Selective poly adenylation predicts the efficacy of immunotherapy in patients with lung adenocarcinoma by multiple omics research

L Wu, Y Zhong, X Yu, D Wu, P Xu, L Lv, X Ruan… - Anti-Cancer …, 2022 - journals.lww.com
The aim of this study was to find the application value of selective polyadenylation in
immune cell infiltration, biological transcription function and risk assessment of survival and …

The eIF4E-binding protein 4E-T is a component of the mRNA decay machinery that bridges the 5′ and 3′ termini of target mRNAs

T Nishimura, Z Padamsi, H Fakim, S Milette… - Cell reports, 2015 - cell.com
Eukaryotic mRNA degradation often initiates with the recruitment of the CCR4-NOT
deadenylase complex and decay factors to the mRNA 3′ terminus. How the 3′-proximal …

A temporal window for signal activation dictates the dimensions of a nodal signaling domain

AL van Boxtel, JE Chesebro, C Heliot, MC Ramel… - Developmental cell, 2015 - cell.com
Morphogen signaling is critical for the growth and patterning of tissues in embryos and
adults, but how morphogen signaling gradients are generated in tissues remains …

Characterization of mRNA therapeutics

GJ Guimaraes, J Kim, MG Bartlett - Mass Spectrometry Reviews, 2024 - Wiley Online Library
Therapeutic messenger RNAs (mRNAs) have emerged as powerful tools in the treatment of
complex diseases, especially for conditions that lack efficacious treatment. The successful …

Oviductal secretion and gamete interaction

S Ghersevich, E Massa, C Zumoffen - Reproduction, 2015 - rep.bioscientifica.com
A reliable, easy to assess marker for fertility in agricultural species would be highly desirable
and Anti-Müllerian Hormone (AMH) is a promising candidate. This review summarizes …