Measuring the tail: Methods for poly (A) tail profiling
A Brouze, PS Krawczyk… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Abstract The 3′‐end poly (A) tail is an important and potent feature of most mRNA
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …
Determinants and implications of mRNA poly (A) tail size–does this protein make my tail look big?
AL Jalkanen, SJ Coleman, J Wilusz - Seminars in cell & developmental …, 2014 - Elsevier
While the phenomenon of polyadenylation has been well-studied, the dynamics of poly (A)
tail size and its impact on transcript function and cell biology are less well-appreciated. The …
tail size and its impact on transcript function and cell biology are less well-appreciated. The …
Accessory subunits are integral for assembly and function of human mitochondrial complex I
Complex I (NADH: ubiquinone oxidoreductase) is the first enzyme of the mitochondrial
respiratory chain and is composed of 45 subunits in humans, making it one of the largest …
respiratory chain and is composed of 45 subunits in humans, making it one of the largest …
Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice
X Jiang, Y Cheng, Y Zhu, C Xu, Q Li, X **ng… - Nature …, 2023 - nature.com
In mammals, the production of mature oocytes necessitates rigorous regulation of the
discontinuous meiotic cell-cycle progression at both the transcriptional and post …
discontinuous meiotic cell-cycle progression at both the transcriptional and post …
Transcription dynamics regulate poly (A) tails and expression of the RNA degradation machinery to balance mRNA levels
Gene expression is regulated by the rates of synthesis and degradation of mRNAs, but how
these processes are coordinated is poorly understood. Here, we show that reduced …
these processes are coordinated is poorly understood. Here, we show that reduced …
Selective poly adenylation predicts the efficacy of immunotherapy in patients with lung adenocarcinoma by multiple omics research
L Wu, Y Zhong, X Yu, D Wu, P Xu, L Lv, X Ruan… - Anti-Cancer …, 2022 - journals.lww.com
The aim of this study was to find the application value of selective polyadenylation in
immune cell infiltration, biological transcription function and risk assessment of survival and …
immune cell infiltration, biological transcription function and risk assessment of survival and …
The eIF4E-binding protein 4E-T is a component of the mRNA decay machinery that bridges the 5′ and 3′ termini of target mRNAs
T Nishimura, Z Padamsi, H Fakim, S Milette… - Cell reports, 2015 - cell.com
Eukaryotic mRNA degradation often initiates with the recruitment of the CCR4-NOT
deadenylase complex and decay factors to the mRNA 3′ terminus. How the 3′-proximal …
deadenylase complex and decay factors to the mRNA 3′ terminus. How the 3′-proximal …
A temporal window for signal activation dictates the dimensions of a nodal signaling domain
Morphogen signaling is critical for the growth and patterning of tissues in embryos and
adults, but how morphogen signaling gradients are generated in tissues remains …
adults, but how morphogen signaling gradients are generated in tissues remains …
Characterization of mRNA therapeutics
Therapeutic messenger RNAs (mRNAs) have emerged as powerful tools in the treatment of
complex diseases, especially for conditions that lack efficacious treatment. The successful …
complex diseases, especially for conditions that lack efficacious treatment. The successful …
Oviductal secretion and gamete interaction
S Ghersevich, E Massa, C Zumoffen - Reproduction, 2015 - rep.bioscientifica.com
A reliable, easy to assess marker for fertility in agricultural species would be highly desirable
and Anti-Müllerian Hormone (AMH) is a promising candidate. This review summarizes …
and Anti-Müllerian Hormone (AMH) is a promising candidate. This review summarizes …