The anterior insular cortex (AIC) is implicated in a wide range of conditions and behaviours,
from bowel distension and orgasm, to cigarette craving and maternal love, to decision …

Feelings are mental experiences of body states. They signify physiological need (for
example, hunger), tissue injury (for example, pain), optimal function (for example, well …

The transition from normal to chronic pain is believed to involve alterations in several brain
areas that participate in the perception of pain. These plastic changes are then responsible …

An ascending sensory pathway that underlies feelings from the body, such as cooling or
toothache, terminates in the posterior insula. Considerable evidence suggests that this …

This article addresses the neuroanatomical evidence for a progression of integrative
representations of affective feelings from the body that lead to an ultimate representation of …

Several brain regions have been implicated in human painful experiences, but none have
been proven to be specific to pain. We exploited arterial spin-labeling quantitative perfusion …

Background Somatic complaints and altered interoceptive awareness are common features
in the clinical presentation of major depressive disorder (MDD). Recently, neurobiological …

When someone asks,“How do you feel?”, your answer includes your bodily feelings as well
as your emotional feelings. Influential models of emotion view the embodiment of emotions …

Investigation of the basic mechanisms of chronic pain not only provides insights into how the
brain processes and modulates sensory information but also provides the basis for …

A meta‐analysis of 140 neuroimaging studies was performed using the activation‐likelihood‐
estimate (ALE) method to explore the location and extent of activation in the brain in …