Deoxyribozymes or DNAzymes are single-stranded catalytic DNA molecules that are
obtained by combinatorial in vitro selection methods. Initially conceived to function as gene …

The development of SELEX (Selective Enhancement of Ligands by Exponential Enrichment)
provides a powerful tool for the search of functional oligonucleotides with the ability to bind …

DNA catalysts (deoxyribozymes) for a variety of reactions have been identified by in vitro
selection. However, for certain reactions this identification has not been achieved. One …

In an effort to expand the binding and recognition capabilities of aptamers, a nucleoside
triphosphate modified with a phenol that mimics the side chain of tyrosine was used in the …

Previously, we evolved a DNA polymerase, SFM4-3, for the recognition of substrates
modified at their 2′ positions with a fluoro, O-methyl, or azido substituent. Here we use …

A huge diversity of modified nucleobases is used as a tool for studying DNA and RNA. Due
to practical reasons, the most suitable positions for modifications are C5 of pyrimidines and …

Modified nucleoside triphosphates (NTPs) are invaluable tools to probe bacterial enzymatic
mechanisms, develop novel genetic material, and engineer drugs and proteins with new …

Development of nucleic acids containing unnatural moieties has expanded the scope of
genetic materials, and modifications of nucleobases have been extensively explored and …

Successful selection of modified DNAzymes depends on the potential for modified
nucleoside triphosphates (dNTPs) to replace their unmodified counterparts in enzyme …

The immune system plays a crucial role in the body's defense system against various
pathogens, such as bacteria, viruses, and parasites, as well as recognizes non-self-and self …