Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

WB Dunn, DI Broadhurst, HJ Atherton… - Chemical society …, 2011 - pubs.rsc.org
The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …

Towards higher sensitivity of mass spectrometry: a perspective from the mass analyzers

C Li, S Chu, S Tan, X Yin, Y Jiang, X Dai… - Frontiers in …, 2021 - frontiersin.org
Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields.
Recent developments in chemical and biological researches have drawn much attention to …

Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

WB Dunn, A Erban, RJM Weber, DJ Creek, M Brown… - Metabolomics, 2013 - Springer
Metabolomics has advanced significantly in the past 10 years with important developments
related to hardware, software and methodologies and an increasing complexity of …

21 tesla FT-ICR mass spectrometer for ultrahigh-resolution analysis of complex organic mixtures

DF Smith, DC Podgorski, RP Rodgers… - Analytical …, 2018 - ACS Publications
We describe complex organic mixture analysis by 21 tesla (T) Fourier transform ion cyclotron
resonance mass spectrometry (FT-ICR MS). Ultrahigh mass-resolving power (m/Δ m 50%> 2 …

High-throughput tissue extraction protocol for NMR-and MS-based metabolomics

H Wu, AD Southam, A Hines, MR Viant - Analytical biochemistry, 2008 - Elsevier
In metabolomics, tissues typically are extracted by grinding in liquid nitrogen followed by the
stepwise addition of solvents. This is time-consuming and difficult to automate, and the …

Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research

A Scalbert, L Brennan, O Fiehn, T Hankemeier… - Metabolomics, 2009 - Springer
Mass spectrometry (MS) techniques, because of their sensitivity and selectivity, have
become methods of choice to characterize the human metabolome and MS-based …

Advances in structure elucidation of small molecules using mass spectrometry

T Kind, O Fiehn - Bioanalytical reviews, 2010 - Springer
The structural elucidation of small molecules using mass spectrometry plays an important
role in modern life sciences and bioanalytical approaches. This review covers different soft …

An international laboratory comparison of dissolved organic matter composition by high resolution mass spectrometry: Are we getting the same answer?

JA Hawkes, J d'Andrilli, JN Agar… - Limnology and …, 2020 - Wiley Online Library
High‐resolution mass spectrometry (HRMS) has become a vital tool for dissolved organic
matter (DOM) characterization. The upward trend in HRMS analysis of DOM presents …

Introducing BASE: the Biomes of Australian Soil Environments soil microbial diversity database

A Bissett, A Fitzgerald, T Meintjes, PM Mele, F Reith… - GigaScience, 2016 - Springer
Background Microbial inhabitants of soils are important to ecosystem and planetary
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …

An introduction to liquid chromatography–mass spectrometry instrumentation applied in plant metabolomic analyses

JW Allwood, R Goodacre - Phytochemical Analysis: An …, 2010 - Wiley Online Library
Over the past decade the application of non‐targeted high‐throughput metabolomic analysis
within the plant sciences has gained ever increasing interest and has truly established itself …